The parts of the body that are most often exposed to sunrays such as the hands or face can get lesions known as lentigenes. These lesions are also known as liver spots. These lesions do not become cancerous and they are benign in nature. These lesions are usually found on the backs of the hand and the face. As an individual ages it is common to see these lesions in increasing numbers which means the condition is more common in older ages and the middle ages. Between 0.2 and 2 cm are the sizes of the lesions. The outline of the lesions is just barely discernible and they are generally flat, dark in color and irregular shaped.

Causes of Lentigenes

These lesions are caused by the pigment cells in the superficial layers of the skin when they have a sudden and remarkable increase. As the lesions develop they may come to have irregular shapes, a change of color or gain some thickness. Since cancer has to be ruled out a biopsy will often be performed when these changes occur. However, most of the time lentigenes are benign in nature.

Treatment of Lentigenes

Treatment is not usually required for these lesions. Cosmetic reasons may be the only time when lentigenes is treated. Effective methods of treatment have included cryotherapy, hydroquinone preparations or bleaching powder, retinoid, chemical peels and laser surgery. Protecting the skin from excessive exposure to the sun through sunscreen and protective clothing can have with prevention and sustaining any treatment. Susceptible parts of the body can be protected by wearing long sleeves and sun hats.

Some Facts About Lentigenes

Often times lentigenes are an inherited disorder and may be present on the skin since birth. They are the dominant trait inherited and since they occur mostly on the trunk and neck they are quickly noticed and are darker than ordinary freckles. Children who have lentigenes are also likely to have wide set eyes, prominent ears, partial deafness and light brown birthmarks. These are just a some of the superficial findings but there are additional findings with this condition.

Additional Findings

An ECG can show changes known as pulmonic steno. Abnormal genitalia and delayed puberty may also occur. When examining the patient they may also have a family history of multiple lentigenes. Patients may also have abnormalities in breast bones, slow growth and delayed or absent puberty.


A mild obstruction of the plutonic heart valve and obstructive cardiomyopathy is found after physical examination. Other tests that should be done include an electrocardiogram and hearing tests. An endocrine evaluation test may also be performed.


Appropriate hearing aids can be used to correct the hearing disorder according to the degree of hearing loss. During the age when puberty must occur, timely intervention can effectively help correct any problems and make the normal changes happen.

Response and Complications

Typically the disease responds well to treatment options. Although certain complications such as deafness, heart problems and infertility can occur with lentigenes.

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